Species: MouseClone:2H11Isotype:IgG1, KappaSpecies Reactivity:HumanCellular Localization:CytoplasmicSpecificity: Thyroglobulin is a 660 kDa dimeric preprotein with multiple glycosylation sites is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine.Prior to forming dimmers, thyroglobulin monomers undergo conformation maturation in the endoplasmic reticulation.Thyroglobulin dimerization as well as transport of thyroglobulin to the Golgi complex is calcium dependent.Thyroglobulin defects resulting from defective dimer formation and export to the Golgi is thought to cause some types of goiter.Antibody against thyroglobulin may be produced by individuals with other diseases arising from the gland such as Hashimoto"s or Graves disease.Hence the presence of thyroglobulin autoantibodies can help to identify disease.Antibody to thyroglobulin has been shown to be useful for the identification of papillary and follicular thyroid carcinoma; thyroglobulin antibody positive lesions are of thyroidal origin.Carcinomas of nonthyroidal origin do not express thyroglobulin and hence are thyroglobulin antibody negative.It is important to note though that not every type of thyroidal lesion is thyroglobulin antibody positive, a number of forms are negative.Hence a negative result does not necessarily rule out that a given lesion or metastasis originated from the thyroid gland.

ScyTek始建于1991年，以成为世界级生命科学研究试剂生产商为目标。ScyTek从创立之初开始, 就采取了严格的原材料筛选程序，确保所有出厂产品都具有最高的品质

按照为工业客户提供OEM服务以及同时服务科研市场的策略，ScyTek能够进行大批量生产而保持总成本降到最低，始终坚持为客户传递其成本优势的政策。

如今， ScyTek生产多种优质试剂，不断应用于各种学科，包括免疫学，组织学，细胞学，微生物学和血液学等.