Species:Rabbit PolyclonalClone:PolyclonalMW:270 kDSpecies Reactivity:HumanPositive Control:Blood vessels in skin or intestineSpecificity:Recognizes a multimeric glycoprotein of 270kDa, identified as factor VIII related antigen or von Willebrand factor. This protein has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Von Willebrand factor is synthesized by endothelial cells and stored in the Weibel-Palade granules. It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabilizer for coagulation factor VIII. ScyTek's antibody reacts specifically with the endothelial cells of normal, reactive, and neoplastic blood and lymphatic vessels and shows a finely granular cytoplasmic staining. It also reacts with endocardium, platelets and megakaryocytes. Von Willebrand factor is one of the most useful markers to identify endothelial (or megakaryocytic) lineage of neoplasms. However, because not all endothelial cells synthesize (or store) this molecule, about 30% of tumors of vascular origin fail to stain for factor VIII related antigen, regardless of whether they are benign or malignant.

ScyTek始建于1991年，以成为世界级生命科学研究试剂生产商为目标。ScyTek从创立之初开始, 就采取了严格的原材料筛选程序，确保所有出厂产品都具有最高的品质

按照为工业客户提供OEM服务以及同时服务科研市场的策略，ScyTek能够进行大批量生产而保持总成本降到最低，始终坚持为客户传递其成本优势的政策。

如今， ScyTek生产多种优质试剂，不断应用于各种学科，包括免疫学，组织学，细胞学，微生物学和血液学等.